H2N2V1, Main, Exploration, bibRecord, 000788

HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex

Identifieur interne : 000788 ( Main/Exploration ); précédent : 000787; suivant : 000789

HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex

Auteurs : Laetitia Zona ; Joachim Lupberger [France] ; N. Sidahmed-Adrar ; Christine Thumann ; H. Harris ; A. Barnes ; J. Florentin ; Rajiv G. Tawar ; Fei Xiao [France] ; Marine Turek ; Sarah C. Durand ; Francois H T. Duong [France] ; M. Heim ; F. Cosset ; I. Hirsch ; D. Samuel ; Laurent Brino ; Mirjam Zeisel [France] ; F. Le Naour ; J. Mckeating ; Thomas Baumert [France]

Source :

Cell Host and Microbe [ 1931-3128 ] ; 2013-03-13.

RBID : Hal:hal-02494664

Abstract

Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR signaling, as a key host signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin beta1 and Ras-related protein Rap2B in hepatocyte membranes. HRas signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.

Url:

https://hal.archives-ouvertes.fr/hal-02494664

DOI: 10.1016/j.chom.2013.02.006

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000124
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Le document en format XML

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<author><name sortKey="Durand, Sarah C" sort="Durand, Sarah C" uniqKey="Durand S" first="Sarah C" last="Durand">Sarah C. Durand</name>
</author>
<author><name sortKey="Duong, Francois H T" sort="Duong, Francois H T" uniqKey="Duong F" first="Francois H T" last="Duong">Francois H T. Duong</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447080" status="VALID">          <idno type="IdRef">226490971</idno>
          <idno type="RNSR">200615803F</idno>
          <orgName>Institut de Recherche sur les Maladies Virales et Hépatiques</orgName>
          <orgName type="acronym">IVH</orgName>
          <desc>            <address>              <addrLine>Institut de virologie, 3 rue Koeberlé, 67000 Strasbourg</addrLine>
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          <orgName type="acronym">UNISTRA</orgName>
          <desc>            <address>              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.unistra.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U1110" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
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</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Heim, M" sort="Heim, M" uniqKey="Heim M" first="M" last="Heim">M. Heim</name>
</author>
<author><name sortKey="Cosset, F" sort="Cosset, F" uniqKey="Cosset F" first="F" last="Cosset">F. Cosset</name>
</author>
<author><name sortKey="Hirsch, I" sort="Hirsch, I" uniqKey="Hirsch I" first="I" last="Hirsch">I. Hirsch</name>
</author>
<author><name sortKey="Samuel, D" sort="Samuel, D" uniqKey="Samuel D" first="D" last="Samuel">D. Samuel</name>
</author>
<author><name sortKey="Brino, Laurent" sort="Brino, Laurent" uniqKey="Brino L" first="Laurent" last="Brino">Laurent Brino</name>
</author>
<author><name sortKey="Zeisel, Mirjam" sort="Zeisel, Mirjam" uniqKey="Zeisel M" first="Mirjam" last="Zeisel">Mirjam Zeisel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447080" status="VALID">          <idno type="IdRef">226490971</idno>
          <idno type="RNSR">200615803F</idno>
          <orgName>Institut de Recherche sur les Maladies Virales et Hépatiques</orgName>
          <orgName type="acronym">IVH</orgName>
          <desc>            <address>              <addrLine>Institut de virologie, 3 rue Koeberlé, 67000 Strasbourg</addrLine>
              <country key="FR"></country>
            </address>
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        <tutelles><tutelle name="UMRS1110" active="#struct-199013" type="direct"><org type="institution" xml:id="struct-199013" status="VALID">          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>            <address>              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.unistra.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U1110" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Le Naour, F" sort="Le Naour, F" uniqKey="Le Naour F" first="F" last="Le Naour">F. Le Naour</name>
</author>
<author><name sortKey="Mckeating, J" sort="Mckeating, J" uniqKey="Mckeating J" first="J" last="Mckeating">J. Mckeating</name>
</author>
<author><name sortKey="Baumert, Thomas" sort="Baumert, Thomas" uniqKey="Baumert T" first="Thomas" last="Baumert">Thomas Baumert</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447080" status="VALID">          <idno type="IdRef">226490971</idno>
          <idno type="RNSR">200615803F</idno>
          <orgName>Institut de Recherche sur les Maladies Virales et Hépatiques</orgName>
          <orgName type="acronym">IVH</orgName>
          <desc>            <address>              <addrLine>Institut de virologie, 3 rue Koeberlé, 67000 Strasbourg</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u1110.inserm.fr</ref>
          </desc>
          <listRelation>            <relation name="UMRS1110" active="#struct-199013" type="direct"></relation>
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        <tutelles><tutelle name="UMRS1110" active="#struct-199013" type="direct"><org type="institution" xml:id="struct-199013" status="VALID">          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>            <address>              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.unistra.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U1110" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.chom.2013.02.006</idno>
<series><title level="j">Cell Host and Microbe</title>
<idno type="ISSN">1931-3128</idno>
<imprint><date type="datePub">2013-03-13</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">              <p>Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR signaling, as a key host signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas associates with tetraspanin CD81, CLDN1, and the previously unrecognized HCV entry cofactors integrin beta1 and Ras-related protein Rap2B in hepatocyte membranes. HRas signaling is required for lateral membrane diffusion of CD81, which enables tetraspanin receptor complex assembly. HRas was also found to be relevant for entry of other viruses, including influenza. Our data demonstrate that viruses exploit HRas signaling for cellular entry by compartmentalization of entry factors and receptor trafficking.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Grand Est</li>
</region>
<settlement><li>Strasbourg</li>
</settlement>
<orgName><li>Université de Strasbourg</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Barnes, A" sort="Barnes, A" uniqKey="Barnes A" first="A" last="Barnes">A. Barnes</name>
<name sortKey="Brino, Laurent" sort="Brino, Laurent" uniqKey="Brino L" first="Laurent" last="Brino">Laurent Brino</name>
<name sortKey="Cosset, F" sort="Cosset, F" uniqKey="Cosset F" first="F" last="Cosset">F. Cosset</name>
<name sortKey="Durand, Sarah C" sort="Durand, Sarah C" uniqKey="Durand S" first="Sarah C" last="Durand">Sarah C. Durand</name>
<name sortKey="Florentin, J" sort="Florentin, J" uniqKey="Florentin J" first="J" last="Florentin">J. Florentin</name>
<name sortKey="Harris, H" sort="Harris, H" uniqKey="Harris H" first="H" last="Harris">H. Harris</name>
<name sortKey="Heim, M" sort="Heim, M" uniqKey="Heim M" first="M" last="Heim">M. Heim</name>
<name sortKey="Hirsch, I" sort="Hirsch, I" uniqKey="Hirsch I" first="I" last="Hirsch">I. Hirsch</name>
<name sortKey="Le Naour, F" sort="Le Naour, F" uniqKey="Le Naour F" first="F" last="Le Naour">F. Le Naour</name>
<name sortKey="Mckeating, J" sort="Mckeating, J" uniqKey="Mckeating J" first="J" last="Mckeating">J. Mckeating</name>
<name sortKey="Samuel, D" sort="Samuel, D" uniqKey="Samuel D" first="D" last="Samuel">D. Samuel</name>
<name sortKey="Sidahmed Adrar, N" sort="Sidahmed Adrar, N" uniqKey="Sidahmed Adrar N" first="N" last="Sidahmed-Adrar">N. Sidahmed-Adrar</name>
<name sortKey="Tawar, Rajiv G" sort="Tawar, Rajiv G" uniqKey="Tawar R" first="Rajiv G" last="Tawar">Rajiv G. Tawar</name>
<name sortKey="Thumann, Christine" sort="Thumann, Christine" uniqKey="Thumann C" first="Christine" last="Thumann">Christine Thumann</name>
<name sortKey="Turek, Marine" sort="Turek, Marine" uniqKey="Turek M" first="Marine" last="Turek">Marine Turek</name>
<name sortKey="Zona, Laetitia" sort="Zona, Laetitia" uniqKey="Zona L" first="Laetitia" last="Zona">Laetitia Zona</name>
</noCountry>
<country name="France"><region name="Grand Est"><name sortKey="Lupberger, Joachim" sort="Lupberger, Joachim" uniqKey="Lupberger J" first="Joachim" last="Lupberger">Joachim Lupberger</name>
</region>
<name sortKey="Baumert, Thomas" sort="Baumert, Thomas" uniqKey="Baumert T" first="Thomas" last="Baumert">Thomas Baumert</name>
<name sortKey="Duong, Francois H T" sort="Duong, Francois H T" uniqKey="Duong F" first="Francois H T" last="Duong">Francois H T. Duong</name>
<name sortKey="Xiao, Fei" sort="Xiao, Fei" uniqKey="Xiao F" first="Fei" last="Xiao">Fei Xiao</name>
<name sortKey="Zeisel, Mirjam" sort="Zeisel, Mirjam" uniqKey="Zeisel M" first="Mirjam" last="Zeisel">Mirjam Zeisel</name>
</country>
</tree>
</affiliations>
</record>

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HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex

HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex

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